Our final project of the term, often referred to as ‘The John-Scott Project’ was to illustrate a physiological concept in 2D (for John’s class) and in 3D (for Scott’s). I chose to do a pathophysiological concept of the reovirus. Reovirus, short for Respiratory Enteric Orphan Virus, is a naturally occurring virus that targets cancer cells and is harmless to normal cells. (You’ve probably encountered reovirus at some point in your life but your immune system has removed it.) Normal cells have Protein Kinase R (PKR) which protects them against viral infections. Cancer cells have an activated Ras Pathway (involved in cellular signal transduction) which blocks PKR activity, thus allowing reovirus to invade, There is a variant of reovirus, called Reolysin, which is currently under Phase 3 clinical trials (final testing) for cancer treatment. What’s so amazing about this virus, is that it has the potential to treat an overwhelming majority of cancers. 75% of primary carcinomas have Ras turned on and 95-100% of metastatic tumors have it on, thus the potential to be invaded and killed by reovirus. I’m very excited to see what happens in the future!
Here’s the 2D illustration using Photoshop. (Note, the reovirus are much smaller than what is depicted)
Here’s the 3D version using 3Ds Max of reovirus finding the angiosarcoma